Spect research

Since the 1980s, there have been thousands of scientific papers on brain SPECT imaging for evaluating many psychiatric and neurological disorders. The Amen Clinics' research library contains our own scientific research along with abstracts of thousands of studies from the U.S. and around the world.

Regional Cerebral Blood Flow during Wakeful Rest in Older Subjects with Mild to Severe Obstructive Sleep Apnea.

OBJECTIVES: To evaluate changes in regional cerebral blood flow (rCBF) during wakeful rest in older subjects with mild to severe obstructive sleep apnea (OSA) and healthy controls, and to identify markers of OSA severity that predict altered rCBF. DESIGN: High-resolution (99m)Tc-HMPAO SPECT imaging during wakeful rest. SETTING: Research sleep laboratory affiliated with a University hospital. PARTICIPANTS: Fifty untreated OSA patients aged between 55 and 85 years, divided into mild, moderate, and severe OSA, and 20 age-matched healthy controls. INTERVENTIONS: N/A. MEASUREMENTS: Using statistical parametric mapping, rCBF was compared between groups and correlated with clinical, respiratory, and sleep variables. RESULTS: Whereas no rCBF change was observed in mild and moderate groups, participants with severe OSA had reduced rCBF compared to controls in the left parietal lobules, left precentral gyrus, bilateral postcentral gyri, and right precuneus. Reduced rCBF in these regions and in areas of the bilateral frontal and left temporal cortex was associated with more hypopneas, snoring, hypoxemia, and sleepiness. Higher apnea, microarousal, and body mass indexes were correlated to increased rCBF in the basal ganglia, insula, and limbic system. CONCLUSIONS: While older individuals with severe obstructive sleep apnea (OSA) had hypoperfusion in the sensorimotor and parietal areas, respiratory variables and subjective sleepiness were correlated with extended regions of hypoperfusion in the lateral cortex. Interestingly, OSA severity, sleep fragmentation, and obesity correlated with increased perfusion in subcortical and medial cortical regions. Anomalies with such a distribution could result in cognitive deficits and reflect impaired vascular regulation, altered neuronal integrity, and/or undergoing neurodegenerative processes.  

Publication: SLEEP

Publication Institution: 2015 Associated Professional Sleep Societies, LLC.

Publication Date: Sep 1, 2015

Publication Author/s: Sep 1, 2015

Category: SPECT - Sleep Disorders


If you want to speak to someone immediately, you can call a qualified Patient Care Coordinator with Amen Clinics. We can start to answer your questions and help you book a Full Evaluation with Amen Clinics. Call Today! 888-208-0037

Book an evaluation

Have a Question?